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The Silent Threat: Who is at Risk for Aneurysms and Why Screening is Vital

Aneurysms often carry the label of "silent killers" because many people do not realize they have one until it is too late. When ruptured, the consequences can be severe and even fatal. Therefore, it is essential to understand who is most at risk and why regular screening can be a lifesaver. This post focuses on those who should be aware of their risk for silent aneurysms and the critical role of timely screening.


Understanding Aneurysms


An aneurysm is an abnormal swelling in a blood vessel, often due to weakened arterial walls. This condition can occur in various locations, with cerebral aneurysms (in the brain) and aortic aneurysms (in the main artery of the body) being the most prevalent. Research shows that approximately 4 in 1000 people have a cerebral aneurysm, but only a fraction will experience rupture. 3-8 in 100 people in screening studies were found to have abdominal aortic aneurysm, with prevalence increasing with age amongst male smokers.


Risk Factors for Aneurysms


While anyone can develop an aneurysm, certain characteristics increase the likelihood. Here are the main risk factors to consider:


Age


The risk of developing an aneurysm climbs significantly after age 40. Average age of rupture of brain aneurysm is around 50 years (more common is women). Men over 65 are at higher risk of abdominal aortic aneurysm.


Family History


Genetics can elevate the risk of aneurysms substantially. If you have first degree relatives who have experienced aneurysms, you are at a much higher risk.


High Blood Pressure


Chronic hypertension creates additional stress on blood vessel walls. Studies have shown that about 75% of individuals with an aortic aneurysm have a history of high blood pressure. Monitoring and controlling blood pressure can significantly lower the risk of developing an aneurysm.


Smoking


Smoking is a major contributor to vascular conditions. According to the CDC, smokers are twice as likely to suffer from an aortic aneurysm compared to non-smokers. Tobacco products weaken blood vessels and promote aneurysm formation. Quitting smoking can drastically cut your risk.


Previous Aneurysms


People who have previously had an aneurysm are at a higher risk of new ones forming, with studies indicating that they are three to six times more likely to develop another aneurysm. Continuous check-ups and follow-up care are essential for these individuals.


Certain genetic disorders


Conditions like Ehlers-Danlos syndrome, Marfan syndrome, and polycystic kidney disease weaken blood vessels due to defective collagen formation in the body.


Atherosclerosis


Hardening of the arteries due to plaque buildup can weaken blood vessel walls.


Sex


Some types of aneurysms, like brain aneurysms, are more common in women, while aortic aneurysms are more common in men.


Drug use


Stimulants like cocaine or amphetamines can cause spikes in blood pressure, increasing the risk.


Other Risk Factors


Head or artery trauma – Can damage blood vessels and lead to aneurysm formation.

Infections – Certain infections can cause arterial inflammation, increasing aneurysm risk.

Chronic inflammation – Conditions like vasculitis can weaken blood vessel walls.



Close-up view of a medical ultrasound machine displaying an aneurysm scan
Medical CT scan focusing on an aneurysm detection.

The Importance of Screening


Aneurysms often go unnoticed until they rupture, making screening critical. Here are key reasons why timely screening should be a priority:


Early Detection


Screening can identify an aneurysm before it ruptures. Techniques such as ultrasound, CT scans, or MRIs are effective in early detection. For instance, data shows that early treatment after an aneurysm is discovered leads to a survival rate of over 90%.


Prevention Strategies


Once detected, healthcare professionals can recommend lifestyle changes or treatments to lower the risk of rupture. This may include regular check-ups, medication, or surgical interventions. For example, adopting a heart-healthy diet and regular exercise can improve vascular health significantly.



Who Should Get Screened?


Certain groups are especially encouraged to seek screening:


For Abdominal aortic aneurysm( AAA)-


1- Men between ages of 65-75 years, who have ever smoked. There is robust evidence that this group benefits most from screening.


2- Men between ages 65-75, who have other risk factors and family history (but never smoked) The benefit of screening is smaller than the first category and should discuss with physician the risks and benefits of screening.


3- For women that smoked or have family history of AAA , it is unclear if screening would help.


For brain aneurysms-

Currently there is no routine screening program for the brain aneurysms.

A case can be made for screening, if 2 or more first degree relatives have experienced subarachnoid hemorrhage(a bleeding inside the brain, usually from ruptured aneurysms).

People with autosomal dominant polycystic kidney disease may have higher risk of brain aneurysm and may consider screening.


Eye-level view of a doctor discussing a screening procedure with a patient
Doctor explaining the importance of aneurysm screening to a patient.

Final Thoughts


Aneurysms represent a hidden danger that can lead to catastrophic outcomes if undetected. They are quite rare and typically silent.

By understanding the risk factors associated with aneurysm development, people can take proactive measures to safeguard their health.

Investing time in fostering healthier lifestyle choices is key. For those at heightened risk, talking to healthcare providers about screening options can be life-changing.

However, discovering that you have an aneurysm unsuitable for surgery, can cause unnecessary worry and distress, even though risk of rupturing is low. Some people have reported regret at getting screened. Discussing risk vs benefit of screening, especially when the indication for screening is not robust, is important.

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